A MONOCLONAL-ANTIBODY TO CANDIDA-ALBICANS ENHANCES MOUSE NEUTROPHIL CANDIDACIDAL ACTIVITY

Authors
CAESARTONTHAT TC CUTLER JE
Citation
Tc. Caesartonthat et Je. Cutler, A MONOCLONAL-ANTIBODY TO CANDIDA-ALBICANS ENHANCES MOUSE NEUTROPHIL CANDIDACIDAL ACTIVITY, Infection and immunity, 65(12), 1997, pp. 5354-5357
Citations number
20
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
12
Year of publication
1997
Pages
5354 - 5357
Database
ISI
SICI code
0019-9567(1997)65:12<5354:AMTCEM>2.0.ZU;2-2
Abstract
A monoclonal antibody (MAb) to Candida albicans (MAb B6.1) that protec ts against candidiasis and the nonprotective MAB B6 were compared for ability to support neutrophil (polymorphonuclear leukocyte [PMN]) cand idacidal activity. Both MAbs are immunoglobulin M, and each recognizes distinct C. albicans mannan cell wall determinants. PMN candidacidal activity was assessed by transmission electron microscopy and by an in vitro killing assay. The results indicated that MAB B6.1, but not MAb B6, enhances ingestion and killing of yeast cells by PMN in the prese nce of serum complement.