The aim of the present study was to investigate if alterations in prot
ein S levels occur in peripheral arterial disease. In a group of 33 pa
tients with peripheral arterial disease and in a group of 10 healthy v
olunteers we have the quantitative determination of functional protein
S. The observer values show non significant difference in protein S l
evels among vasculopathic patients and controls (only five out of 33 p
atients showed low protein S levels). These data seem to suggest that
low protein S levels do not play an important role in the development
of peripheral arterial disease.