HYPERTENSION AND EDEMA CAUSED BY CORTEXONE HYPERPRODUCTION AND CURED BY MONOLATERAL ADRENALECTOMY - CASE-REPORT

Excess Il-deoxycorticosterone (DOG) production, mostly due to an enzym e defect 11-beta-hydroxylase, is a rare cause of secondary hypertensio n, Even rarer are those forms due to an adrenal adenoma or to a bilate ral hyperplasia, In this paper we report the case of 23-year-old woman with excess DOC production, presenting with arterial hypertension and oedema, whom we first observed in 1961, Complete clinical remission, persisting more than 30 years later, was obtained by monolateral adren alectomy, The literature reports of DOG-induced hypertension due to ad renal adenoma or hyperplasia are reviewed and the possible pathogeneti c mechanisms are discussed.