EFFECTS OF INTRAPALLIDAL CANNABINOIDS ON ROTATIONAL BEHAVIOR IN RATS - INTERACTIONS WITH THE DOPAMINERGIC SYSTEM

The effect of unilateral. intrapallidal cannabinoid receptor stimulati on on rotational behavior in rats was explored. The potent cannabinoid agonist CP55,940 (5 mu g/0.5 mu l) induced ipsilateral turning when m icroinjected unilaterally into the globus pallidus. The D-2 dopamine a gonist quinpirole reversed this ipsilateral rotation but failed to aff ect motor behavior on its own. Finally, the D-1 dopamine agonist SKF 8 2958 inhibited movement when administered into the globus pallidus, an d this effect was not additive with CP55,940. (C) 1998 Wiley-Liss, Inc .