CHARACTERIZATION AND SENSITIVITY TO INTERLEUKIN-2 AND INTERFERON-ALPHA OF LEUKEMIC-CELLS FROM A PATIENT WITH LARGE GRANULAR LYMPHOCYTIC-LEUKEMIA ASSOCIATED WITH CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION
K. Toba et al., CHARACTERIZATION AND SENSITIVITY TO INTERLEUKIN-2 AND INTERFERON-ALPHA OF LEUKEMIC-CELLS FROM A PATIENT WITH LARGE GRANULAR LYMPHOCYTIC-LEUKEMIA ASSOCIATED WITH CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION, Leukemia research, 21(10), 1997, pp. 941-950
A patient presented with chronic large granular lymphocyte leukemia as
sociated with chronic active Epstein-Barr virus infection (CAEBV). Cel
l cycle analysis revealed led a minimal growth compatible with chronic
lymphocytic leukemia After 5 months of treatment, the patient died fr
om acute transformation of the leukemia. Cells harvested during chroni
c phase were analyzed for sensitivity to interleukin 2 (IL-2) and inte
rferon alpha (IFN alpha) in vitro by means of surface phenotyping and
cell cycle assay. IL-2 induced remarkable growth of the cells, whereas
IFN alpha did not confer a growth advantage. Since IFN alpha was expe
cted to have no growth induction effect on the leukemia cells, it was
administered to the patient to treat the CAEBV. (C) 1997 Elsevier Scie
nce Ltd.