CHARACTERIZATION AND SENSITIVITY TO INTERLEUKIN-2 AND INTERFERON-ALPHA OF LEUKEMIC-CELLS FROM A PATIENT WITH LARGE GRANULAR LYMPHOCYTIC-LEUKEMIA ASSOCIATED WITH CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION

Citation
K. Toba et al., CHARACTERIZATION AND SENSITIVITY TO INTERLEUKIN-2 AND INTERFERON-ALPHA OF LEUKEMIC-CELLS FROM A PATIENT WITH LARGE GRANULAR LYMPHOCYTIC-LEUKEMIA ASSOCIATED WITH CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION, Leukemia research, 21(10), 1997, pp. 941-950
Citations number
45
Categorie Soggetti
Oncology,Hematology
Journal title
ISSN journal
01452126
Volume
21
Issue
10
Year of publication
1997
Pages
941 - 950
Database
ISI
SICI code
0145-2126(1997)21:10<941:CASTIA>2.0.ZU;2-0
Abstract
A patient presented with chronic large granular lymphocyte leukemia as sociated with chronic active Epstein-Barr virus infection (CAEBV). Cel l cycle analysis revealed led a minimal growth compatible with chronic lymphocytic leukemia After 5 months of treatment, the patient died fr om acute transformation of the leukemia. Cells harvested during chroni c phase were analyzed for sensitivity to interleukin 2 (IL-2) and inte rferon alpha (IFN alpha) in vitro by means of surface phenotyping and cell cycle assay. IL-2 induced remarkable growth of the cells, whereas IFN alpha did not confer a growth advantage. Since IFN alpha was expe cted to have no growth induction effect on the leukemia cells, it was administered to the patient to treat the CAEBV. (C) 1997 Elsevier Scie nce Ltd.