A case of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and
stroke-like episodes) which presented as migraine complicated by stro
ke is reported, Strokes associated with migraine have often been repor
ted, but the mechanism remains unclear and may include a variety of pa
thologies. MELAS also presents with migrainous headache, vomiting, and
strokelike symptoms. Magnetic resonance imaging demonstrates characte
ristic findings. MELAS should be considered in the differential diagno
sis of infarct-like lesions with migrainous headaches in young adults,
especially if the symptoms fluctuate and are accompanied by a homonym
ous hemianopia.