THE USE OF LIQUID-CHROMATOGRAPHY COMBINED WITH A QUADRUPOLE TIME-OF-FLIGHT ANALYZER FOR THE IDENTIFICATION OF TRACE IMPURITIES IN DRUG SUBSTANCE

Authors
ECKERS C HASKINS N LANGRIDGE J
Citation
C. Eckers et al., THE USE OF LIQUID-CHROMATOGRAPHY COMBINED WITH A QUADRUPOLE TIME-OF-FLIGHT ANALYZER FOR THE IDENTIFICATION OF TRACE IMPURITIES IN DRUG SUBSTANCE, Rapid communications in mass spectrometry, 11(17), 1997, pp. 1916-1922
Citations number
2
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
11
Issue
17
Year of publication
1997
Pages
1916 - 1922
Database
ISI
SICI code
0951-4198(1997)11:17<1916:TUOLCW>2.0.ZU;2-5
Abstract
This paper shows the use of a quadrupole time-of-flight mass spectrome ter combined with a liquid chromatograph for the identification of tra ce impurities in a drug substance. LC/MS/MS data obtained on trace imp urities using this instrument compare favourably with those previously obtained on triple quadrupole mass spectrometers and in addition the high resolution capabilities of the ToF analyser allow accurate mass m easurement of the fragment ions to better than 5 ppm in most cases. (C ) 1997 John Wiley & Sons, Ltd.