THE CELLS OF THE ALLERGIC RESPONSE - MAST-CELLS, BASOPHILS, AND EOSINOPHILS

Mast cells, basophils, and eosinophils have long been regarded as impo rtant effector cells in allergic disorders. Indeed, it is thought that the cells' cytoplasmic granule-associated or lipid mediators contribu te to many of the signs and symptoms that are characteristic of these diseases. Mast cells, basophils, and eosinophils also probably contrib ute to protective host responses, especially to parasites. In addition , recent evidence shows that mast cells, basophils, and eosinophils ca n secrete a wide spectrum of cytokines and, in some cases, express fun ctions that may permit them to regulate the development or perpetuatio n of allergic responses. Thus, mast cells, basophils, and eosinophils may express immunoregulatory activities, as well as serve as effector cells.