A random sample of 26,000 Swedish women who were asked about their smo
king habits in the early 1960s have now been followed for 26 years wit
h respect to cancer incidence. Most findings regarding tobacco smoking
and cancer from studies of men were confirmed also among the women. E
levated relative risk for current smokers compared with women who neve
r smoked regularly were seen for cancers of the lung, upper aerodigest
ive sites, pancreas, bladder, cervix and all cancers combined, as well
as a notably high relative risk for cancers of organs of the urinary
tract other than kidney and bladder. Relative risk increased with dose
, measured as grams of tobacco smoked per day, for cancers of the uppe
r aerodigestive sites, lung, cervix, bladder, organs of the urinary tr
act other than kidney and bladder and all cancers combined. For cancer
s of the lung, bladder and cervix, there was an inverse relationship w
ith age when starting to smoke tobacco. The reported inverse relations
hip between smoking and endometrial cancer could not be corroborated,
nor was there any significant relationship between smoking and colorec
tal or breast cancer. (C) 1997 Wiley-Liss, Inc.