SPONGISTATIN SYNTHETIC STUDIES .2. ASSEMBLY OF THE C(18-28) SPIROKETAL

Authors
SMITH AB ZHUANG LH BROOK CS LIN QY MOSER WH TROUT REL BOLDI AM
Citation
Ab. Smith et al., SPONGISTATIN SYNTHETIC STUDIES .2. ASSEMBLY OF THE C(18-28) SPIROKETAL, Tetrahedron letters, 38(50), 1997, pp. 8671-8674
Citations number
17
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
50
Year of publication
1997
Pages
8671 - 8674
Database
ISI
SICI code
0040-4039(1997)38:50<8671:SSS.AO>2.0.ZU;2-B
Abstract
The C(18-28) CD-ring spiroketal subunit of the spongistatins, marine p olyether macrolides with unprecedented antitumor activity, has been ge nerated via a highly convergent and completely stereocontrolled sequen ce. Key operations include a one-flask dithiane bisalkylation and a me tal-assisted spiroketal equilibration. (C) 1997 Elsevier Science Ltd.