SPONGISTATIN SYNTHETIC STUDIES .3. CONSTRUCTION OF THE C(1-17) SPIROKETAL

Authors
SMITH AB LIN QY NAKAYAMA K BOLDI AM BROOK CS MCBRIAR MD MOSER WH SOBUKAWA M ZHUANG LH
Citation
Ab. Smith et al., SPONGISTATIN SYNTHETIC STUDIES .3. CONSTRUCTION OF THE C(1-17) SPIROKETAL, Tetrahedron letters, 38(50), 1997, pp. 8675-8678
Citations number
27
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
50
Year of publication
1997
Pages
8675 - 8678
Database
ISI
SICI code
0040-4039(1997)38:50<8675:SSS.CO>2.0.ZU;2-5
Abstract
A convergent synthesis of the C(1-17) AB-ring subunit of the spongista tins, exceedingly scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontro lled spiroketalization, and Julia sulfone coupling/methylenation. (C) 1997 Elsevier Science Ltd.