A CHEMICAL-MODEL FOR THE ENZYMATIC MONO DE-ALKYLATION OF (METHYL AND ETHYL) PARATHION BY GLUTATHIONE-S-TRANSFERASE

Authors
MATURANO MD BONGIBAULT V WILLSON M KLAEBE A FOURNIER D
Citation
Md. Maturano et al., A CHEMICAL-MODEL FOR THE ENZYMATIC MONO DE-ALKYLATION OF (METHYL AND ETHYL) PARATHION BY GLUTATHIONE-S-TRANSFERASE, Tetrahedron, 53(51), 1997, pp. 17241-17246
Citations number
18
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
51
Year of publication
1997
Pages
17241 - 17246
Database
ISI
SICI code
0040-4020(1997)53:51<17241:ACFTEM>2.0.ZU;2-2
Abstract
The NMR study of the reaction of methylparathion with thiol (glutathio ne) and a tertiary amine shows unambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The r eaction stops after a single demethylation. This observation may accou nt for regiospecificity of some glutathione-S-transferases. (C) 1997 E lsevier Science Ltd.