SOLID-PHASE SYNTHESIS OF POLYAMINE CONJUGATES FOR THE STUDY OF TRYPANOTHIONE REDUCTASE

Authors
MARSH IR BRADLEY M
Citation
Ir. Marsh et M. Bradley, SOLID-PHASE SYNTHESIS OF POLYAMINE CONJUGATES FOR THE STUDY OF TRYPANOTHIONE REDUCTASE, Tetrahedron, 53(51), 1997, pp. 17317-17334
Citations number
26
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
51
Year of publication
1997
Pages
17317 - 17334
Database
ISI
SICI code
0040-4020(1997)53:51<17317:SSOPCF>2.0.ZU;2-1
Abstract
A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fm oc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N-1, N-8-bis(glutath ionyl)spermidine [trypanothione], and a range of related analogues wer e prepared for biological evaluation as previously communicated. (C) 1 997 Elsevier Science Ltd.