Ir. Marsh et M. Bradley, SOLID-PHASE SYNTHESIS OF POLYAMINE CONJUGATES FOR THE STUDY OF TRYPANOTHIONE REDUCTASE, Tetrahedron, 53(51), 1997, pp. 17317-17334
A number of polyamine scaffolds were synthesised, enabling the facile
preparation of a variety of polyamine conjugates using both Boc and Fm
oc protecting group strategies. Products were released from the solid
support by treatment with either triflic acid/trifluoroacetic acid or
trifluoroacetic acid. The trypanosomal metabolite N-1, N-8-bis(glutath
ionyl)spermidine [trypanothione], and a range of related analogues wer
e prepared for biological evaluation as previously communicated. (C) 1
997 Elsevier Science Ltd.