SYNTHESIS OF BORONATED PHENANTHRIDINIUM DERIVATIVES FOR POTENTIAL USEIN BORON NEUTRON-CAPTURE THERAPY (BNCT)

-(3-aminopropyl)-p-carborane-1-yl)propyl]-6-phenyl phenanthridinium ch loride hydrochloride (13) has been synthesised by reacting 3,8-diaceta mido-6-phenylphenanthridine (9) with 1-(3-N,N-dibenzyloxycarbonylamino propyl) 12-(3-iodopropyl)-1, 12-dicarba-closo-dodecaborane (8a) in nit robenzene at 120 degrees C for 4 days and subsequent removal of the pr otective groups using 33% HBr/AcOH. Conversion to the chloride hydroch loride was accomplished by the action of hydrochloric acid on the pseu do-base of 13. (C) 1997 Elsevier Science Ltd.