This report describes our initial experience using positron emission t
omography (PET) scanning in esophageal cancer patients. In two patient
s PET identified distant metastatic disease missed by conventional sta
ging. Laparoscopic biopsy provided histological confirmation of metast
ases. In the third patient, locoregional lymph nodes were identified b
y PET and confirmed by surgical staging. In this preliminary report, P
ET appears to be a promising new noninvasive modality for staging pati
ents with esophageal cancer.