TREATMENT WITH LOW-DOSE DIAZOXIDE IN 2 GROWTH-RETARDED PREPUBERTAL GIRLS WITH GLYCOGEN-STORAGE-DISEASE TYPE IA RESULTED IN CATCH-UP GROWTH

Authors
NUOFFER JM MULLIS PE WIESMANN UN
Citation
Jm. Nuoffer et al., TREATMENT WITH LOW-DOSE DIAZOXIDE IN 2 GROWTH-RETARDED PREPUBERTAL GIRLS WITH GLYCOGEN-STORAGE-DISEASE TYPE IA RESULTED IN CATCH-UP GROWTH, Journal of inherited metabolic disease, 20(6), 1997, pp. 790-798
Citations number
15
Categorie Soggetti
Endocrynology & Metabolism","Genetics & Heredity
Journal title
Journal of inherited metabolic disease → ACNP
ISSN journal
01418955
Volume
20
Issue
6
Year of publication
1997
Pages
790 - 798
Database
ISI
SICI code
0141-8955(1997)20:6<790:TWLDI2>2.0.ZU;2-M
Abstract
Two originally prepubertal girls suffering from glycogen storage disea se type Ia and short stature were treated with low-dose diazoxide (3-4 .8 mg/kg per day) for 7 and 4 years, respectively. Both showed an impr essive catch-up growth following this treatment. This appeared to be d ue to prolongation of normoglycaemia after meals and reduction of fast ing lactic acidosis by diazoxide.