DISTRIBUTION OF PLATINUM IN HUMAN GYNECOLOGIC TISSUES AND PELVIC LYMPH-NODES AFTER ADMINISTRATION OF CISPLATIN

Background: Defining tissue accumulation of platinum may be of importa nce, since it may provide a pharmacological explanation for organ-spec ific cisplatin activity. This study was conducted to evaluate the effi cacy of cisplatin at the tissue level in different gynecologic organs. The doses administered were equivalent to those used in neoadjuvant c hemotherapy regimens. Study Design: Cisplatin was administered intrave nously to patients with cervical or endometrial cancer 1 h before oper ation, and platinum accumulations in tissues were assayed by the atomi c absorption method. Results: Platinum accumulation was highest in the cervix and next highest in the myometrium in both cancers. Platinum a ccumulation in ovary and lymph node was only 0.58 and 0.57 times that in the myometrium, respectively. In patients with cervical cancer, the platinum accumulations in the myometrium and cervix were significantl y higher than in the ovary and lymph node. Platinum accumulation in ce rvical cancer tissue was lower than in the myometrium and cervix, sugg esting that delivery of cisplatin to a cervical cancer is somewhat mor e difficult than to the normal cervix. In patients with endometrial ca ncer, there was significantly more accumulation in the cervix than in the ovary and lymph node. Conclusions: These data indicated that cispl atin was easily distributed to the cervix and myometrium, but not to t he ovary, lymph node, and cancer tissues.