IN-VITRO EFFECTS OF BORON-CONTAINING COMPOUNDS UPON GLIOBLASTOMA CELLS

Boron-neutron capture therapy (BNCT) Is currently under investigation as a novel therapeutic modality fop glioblastoma, This study was under taken ia determine whether boron-containing compounds 4-borono-2-fluor o-D,L-phenylalanine (FBPA) and FBPA-fructose have direct effects upon kinetics or A172, a glioblastoma cell line, Flow cytometry analyzed ce ll-cycle distribution and S-phase kinetics (bromo deoxyuridine [BUdR] incorporation), BUdR incorporation was increased during a l-hp pulse a fter 24-hr or 72-hr exposure ai. cells to varying concentrations of FB PA or FBPA-fructose. Results suggest that boron-containing compounds m ay effect cell kinetics apart from neutron activation, and this effect should ha further evaluated dbr potential impact upon tumor responsiv eness to BNCT.