FINE MAPPING OF THE GENE FOR AUTOSOMAL-DOMINANT JUVENILE-ONSET GLAUCOMA WITH IRIDOGONIODYSGENESIS IN 6P25-TEL

Glaucoma is a group of ocular disorders leading to reduced visual capa bilities and sometimes blindness. The biochemical defect is unknown bu t it is shown that reduced drainage of the aqueous humour from the ant erior chamber may lead to increased introcular pressure and gradual at rophy of the optic neurons. Families with various forms of autosomal d ominant (AD) glaucoma have been linked to 1q21-31, 2cen-q13, 4q25-27, and 13q14 and autosomal recessive congenital glaucoma have been locali zed to chromosome 1p36 and 2p21, Recently, a locus for AD iridogoniody sgenesis anomaly (IGDA)was mapped to chromosome 6p25. This study refin es the localization of IGDA to an approximately 6-cM interval between D6S1600 and D6S 1617/D6S1713 at 6p25-teI, based on recombinations in a ffected individuals with AD juvenile-onset glaucoma and concomitant ir idogoniodysgenesis.