The worldwide prevalence of obsessive-compulsive disorder (OCD) is app
roximately 2% of the general population. Symptoms of OCD include fear
of contamination by dirt or germs; constant checking; repetitive, intr
usive thoughts of a somatic, aggressive, or sexual nature; extreme slo
wness; and an inordinate concern with orderliness and symmetry. Differ
ential diagnosis is sometimes complicated by the overlap between OCD a
nd obsessive-compulsive personality disorder (OCPD). The most common c
omplication of OCD is depression. However, while both serotonergic and
nonserotonergic antidepressants are effective in treating patients wi
th depression, only serotonergic medications are effective in treating
OCD patients. Because OCD patients often attempt to conceal their sym
ptoms, it is incumbent on clinicians to screen for OCD in every mental
status examination, since appropriate treatment can often result in i
mproved quality of life.