CYTOGENETIC FINDINGS IN MALIGNANT MIXED MESODERMAL TUMORS OF THE UTERUS

Cytogenetic analyses of four malignant mixed mesodermal tumors (MMMT) of the uterus are reported, of which one was of the homologous type an d three of the heterologous type. Karyotypic analyses were obtained in two cases from original rumors and in two cases from tumors xenotrans planted into nude mice. The karyotype of the homologous MMMT was norma l in three different passages of a nude mice xenograft line establishe d from the primary tumor. The heterologous tumors showed normal karyot ype in one case and hyperdiploid and near triploid range with extensiv e numerical and structural rearrangements in two cases. Deletion of ch romosome 1 at p32, and deletion of chromosome 11 at q23 were common ma rkers in anomalous cases. The chromosomes most often involved in struc tural rearrangements were chromosomes 1, 9, 11, 12, 17, and 19. Double minutes, homogeneously staining regions, and telomeric association we re also seen. (C) Elsevier Science Inc., 1997.