METAANALYSIS OF STEADY-STATE PHARMACOKINETICS OF TROGLITAZONE AND ITSMETABOLITES

The object of this study is to evaluate the effects of age, gender, ag e-by-gender interaction, Type II diabetes, body weight, race, smoking, and formulation on steady-state pharmacokinetics of troglitazone, Met abolite 1 (sulfate conjugate), and Metabolite 3 (quinone metabolite) f ollowing multiple-dose oral administration of troglitazone. Pharmacoki netic ic parameter estimates [Cl/F (apparent oral clearance), AUC(0-24 ) (area under plasma concentration-time curve), and ratio of AUC for t roglitazone to Metabolite 2 and to Metabolite 3] obtained from 84 heal thy volunteers and 171 patients with Type II diabetes in 8 studies rr ere analyzed using a graphical method (for race and smoking) or a weig hted ANCOVA model incorporating gender, health status (healthy vs Type II diabetes), and formulation as main effects; age, age-by-gender int eraction, and body weight as continuous covariates. Ratio of AUC for t roglitazone to metabolites was also and formulation had negligible eff ects on troglitazone Cl/F, AUC(0-24) (all analytes), and AUC ratio of troglitazone to metabolites. Race and smoking did not appear to influe nce steady-state pharmacokinetics of troglitazone and its metabolites. Although body weight was a significant covariate for AUC(0-24) and Cl /F, the explanatory power of the overall model was weak (R-2 < 0.2). L og-probit plots did not reveal a polymorphic distribution in A UC rati o of troglitazone to Metabolite 1 or Metabolite 3. Based on pharmacoki netics, dose adjustment for troglitazone in relation to the demographi c factors examined is not required due to their poor predictive abilit y on steady-state pharmacokinetics of troglitazone and its metabolites .