ATORVASTATIN DOES NOT ALTER THE ANTICOAGULANT ACTIVITY OF WARFARIN

Authors
STERN R ABEL R GIBSON GL BESSERER J
Citation
R. Stern et al., ATORVASTATIN DOES NOT ALTER THE ANTICOAGULANT ACTIVITY OF WARFARIN, Journal of clinical pharmacology, 37(11), 1997, pp. 1062-1064
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of clinical pharmacology → ACNP
ISSN journal
00912700
Volume
37
Issue
11
Year of publication
1997
Pages
1062 - 1064
Database
ISI
SICI code
0091-2700(1997)37:11<1062:ADNATA>2.0.ZU;2-Z
Abstract
Twelve patients chronically maintained on warfarin were administered 8 0 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slight ly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activi ty of warfarin and adjustments in warfarin dosing should not be necess ary.