ON THE SYNTHESIS OF (S)-ALPHA-METHYLASPARTIC ACID BY DIASTEREOSELECTIVE ALKYLATION OF A CHIRAL 2-CYANOPROPANOATE

Authors
CATIVIELA C DIAZDEVILLEGAS MD GALVEZ JA LAPENA Y
Citation
C. Cativiela et al., ON THE SYNTHESIS OF (S)-ALPHA-METHYLASPARTIC ACID BY DIASTEREOSELECTIVE ALKYLATION OF A CHIRAL 2-CYANOPROPANOATE, Tetrahedron, 53(16), 1997, pp. 5891-5898
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
16
Year of publication
1997
Pages
5891 - 5898
Database
ISI
SICI code
0040-4020(1997)53:16<5891:OTSO(A>2.0.ZU;2-P
Abstract
A novel and efficient procedure for the synthesis of optically pure al pha-methylaspartic acid, based on the diastereoselective alkylation of (1S,2R,4R)-10-(dicyclohexylsulfamoyl)iso 2-cyanopropanoate with alpha -halocarbonyl compounds, is described. (C) 1997 Elsevier Science Ltd.