VASCULAR VARIANT OF ALZHEIMERS-DISEASE CHARACTERIZED BY SEVERE PLAQUE-LIKE BETA-PROTEIN ANGIOPATHY

In the neuropathological investigations of 32 demented patients with s evere cerebral amyloid angiopathy (CAA), we found an unusual case, a 9 0-year-old woman, presenting with the pathology of atypical Alzheimer' s disease (AD). The case showed severe plaque-like angiopathy, in whic h all the senile plaques except for some diffuse plaques were formed a round amyloid beta(/A4) protein-laden vessels. Analysis of the amyloid beta protein precursor gene from the patient revealed no mutation. Ou r results have indicated that, among demented patients with severe CAA , there is the vascular variant of AD characterized by severe plaque-l ike beta protein angiopathy.