OBSTETRIC COMPLICATIONS OF ANTIPHOSPHOLIPID ANTIBODIES

Pregnancies occurring in women with antiphospholipid antibodies are at significantly increased risk of miscarriage, prematurity, intrauterin e growth retardation and preeclampsia. Insights into the pathological basis of these conditions suggest that antiphospholipid antibodies imp air embryonic implantation and in later gestations cause thrombosis of the uteroplacental vasculature. This offers a rational basis for thro mboprophylaxis during pregnancy.