LOCALIZATION OF CANDIDATE GENOMIC REGIONS INFLUENCING PARADOXICAL SLEEP IN MICE

QUANTITATIVE trait loci (QTL) approach was used in CXB recombinant inb red mice for preliminary identification of candidate regions on the mo use genome that influence sleep. The only provisional QTLs identified were associated with paradoxical sleep (PS). PS during the light perio d was associated with markers on chromosome 7 between 7 and 20 centimo rgan from the centromere. For PS during the dark period, a single QTL was identified on chromosome 5, near the Clock gene. The 24 h amount o f PS was influenced by markers on chromosomes 2, 17, and 19. This firs t QTL mapping study strongly suggests that a complex behaviour like PS can be controlled by only a few genes.