EPIRUBICIN (CEOP-BLEO) VERSUS IDAURUBICIN (CIOP-BLEO) IN THE TREATMENT OF ELDERLY PATIENTS WITH AGGRESSIVE NON-HODGKINS-LYMPHOMA - DOSE-ESCALATION STUDIES

One hundred and sixty nine untreated elderly patients (median age 69 y ears old; range 60-89 years old) with high or high-intermediate clinic al risk non-Hodgkin's lymphoma were enrolled in a controlled clinical trial to evaluate escalated doses of epirubicin in a CEOP-Bleo regimen (cyclophosphamide, vincristine, epirubicin, prednisone and bleomycin) , compared to escalated doses of idaurubicin in an CIOP-Bleo regimen ( idaurubicin instead of epirubicin). Overall, 71% of the patients in th e CEOP-Bleo arm achieved a complete response compared to only 48% in t he CIOP-Bleo regimen (p<0.01). At actuarial 3 year, 72% of the patient s treated with the CEOP-Bleo regimen remained alive and free of diseas e, compared to 34% in the CIOP-Bleo arm (p<0.01). Dose intensity was 0 .86 in the epirubicin regimen, similar to 0.82 in the idaurubicin arm. Toxicities were more frequent and severe in the CEOP-Bleo regimen; ho wever, no death-related treatment was observed in either groups. Cardi ac toxicity was also similar in both arms. We conclude that treatment of elderly paitents with aggressive non-Hodgkin's lymphoma should be c onsidered a curative attempt and not only palliative. The use of full doses of chemotherapy should be contemplated in elderly patients. Epir ubicin, in escalating doses, is a drug with mild toxicity and improvem ent in outcome in this setting is observed. We cannot confirm the usef ulness of idaurubicin, including escalating doses, in the treatment of patients with aggressive malignant lymphoma, because the complete res ponse rate and survival were worse than other chemotherapy regimens. W e feel that the CEOP-Bleo regimen with escalated doses of epirubicin i s a useful option in the treatment of elderly patients with aggressive non-Hodgkin's lymphoma.