A CLOSER VIEW OF AN ONCOPROTEIN TUMOR-SUPPRESSOR INTERACTION

Authors
SHAIR MD
Citation
Md. Shair, A CLOSER VIEW OF AN ONCOPROTEIN TUMOR-SUPPRESSOR INTERACTION, Chemistry & biology, 4(11), 1997, pp. 791-794
Citations number
19
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
4
Issue
11
Year of publication
1997
Pages
791 - 794
Database
ISI
SICI code
1074-5521(1997)4:11<791:ACVOAO>2.0.ZU;2-9
Abstract
The cellular response to DNA damage is coordinated by the p53 protein. Mdm2, an oncoprotein, inhibits p53 and promotes p53 degradation. A re cent high-resolution structure of the Mdm2-p53 complex may aid the des ign of small molecules to disrupt this interaction, for use in investi gating the interaction further and for designing anticancer drugs.