Sw. Duck et al., INTERACTION BETWEEN HYPERTENSION AND DIABETES-MELLITUS IN THE PATHOGENESIS OF SENSORINEURAL HEARING-LOSS, The Laryngoscope, 107(12), 1997, pp. 1596-1605
The purpose of this study is to support the hypothesis that diabetic e
nd-organ damage of the cochlea is augmented in the setting of hyperten
sion. A historical perspective reviewing the effects of diabetes and h
ypertension as causative factors in the development of sensorineural h
earing loss, as well as the basic epidemiology and pathophysiology of
the renal and vascular effects of diabetes and hypertension, is presen
ted. The results of audiologic findings in insulin-dependent diabetic
patients, both normotensive and hypertensive, were analyzed and correl
ated with the results of animal studies to support the hypothesis that
sensorineural hearing loss in patients and cochlear hair cell loss in
animal studies result from the effects of hypertension in conjunction
with insulin-dependent diabetes mellitus.