ADENOVIRAL E1A-ASSOCIATED PROTEIN P300 IS INVOLVED IN ACUTE MYELOID-LEUKEMIA WITH T(11-22)(Q23-Q13)

p300, which was originally cloned as a nuclear binding target of the a denovirus E1A oncoprotein, forms a family with cyclic-AMP response ele ment binding protein (CREB)-binding protein (CBP), p300/CBP are consid ered to be transcriptional coactivators that connect the basal transcr iptional machinery to various DNA-binding transcriptional factors. p30 0/CBP are implicated in both cell differentiation and regulation of ce ll-cycle. We identify here that the p300 gene is fused to the MLL gene and that in-frame MLL-p300 fusion protein is generated in acute myelo id leukemia (AML) with t(11;22)(q23;q13). These findings suggest that the basis for the leukemogenesis of t(11;22)-AM L is the inability of p300 to regulate cell-cycle and cell differentiation after fusion with MLL. (C) 1997 by The American Society of Hematology.