GAS-CHROMATOGRAPHY MASS-SPECTROMETRY DETERMINATION OF ISOSORBIDE 5-MONONITRATE AND RELATED IMPURITIES IN RAW-MATERIALS AND DOSAGE FORMULATIONS

A straightforward quantitative method for gas chromatography-mass spec trometry determination of isosorbide 5-mononitrate (ISSMN) and its rel ated impurities such as isosorbide (IS), isosorbide diacetate (ISDA) a nd isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/ - 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three differe nt formulations of ISSMN. (C) 1997 Elsevier Science B.V.