Hb. Sun et al., THE FIRST REGIOSPECIFIC SYNTHESIS OF 8,8-DIMETHYL-2H,8H-PYRANO[2,3-H]QUINOLIN-2-ONE AND RELATED-COMPOUNDS, Synthesis, (11), 1997, pp. 1249-1251
The title compound was synthesized in eight steps, starting from 6-ace
tamido-2,2-dimethyl-2H-1-benzopyran-4-one (6). The key steps involved
are the regiospecific nitration of 6 and palladium(0)-catalyzed arylat
ion of acrylic acid in aqueous media.