STRUCTURE VERSUS ENANTIOSELECTIVITY IN PSEUDOMONAS-CEPACIA LIPASE-CATALYZED TRANSESTERIFICATIONS - ENANTIOSELECTIVE ACYLATIONS OF PRIMARY 2-METHYLALCOHOLS

Authors
NGUYEN BV NORDIN O VORDE C HEDENSTROM E HOGBERG HE
Citation
Bv. Nguyen et al., STRUCTURE VERSUS ENANTIOSELECTIVITY IN PSEUDOMONAS-CEPACIA LIPASE-CATALYZED TRANSESTERIFICATIONS - ENANTIOSELECTIVE ACYLATIONS OF PRIMARY 2-METHYLALCOHOLS, Tetrahedron : asymmetry, 8(7), 1997, pp. 983-986
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
7
Year of publication
1997
Pages
983 - 986
Database
ISI
SICI code
0957-4166(1997)8:7<983:SVEIPL>2.0.ZU;2-1
Abstract
The enantioselectivities of lipase from Pseudomonas cepacia (Amano PS) towards a series of primary 2-methyl-omega-(2-thienyl)alkanols using vinyl acetate as the acyl donor in transesterifications in organic sol vents have been studied. It was found to be important to place the thi ophene ring in the correct position in the chain. In terms of enantios electivity, we found that the number of methylene groups between the s tereogenic centre and the aromatic ring in chiral omega-aryl-2-methyla lkanols ought to be one. (C) 1997 Elsevier Science Ltd.