CATALYTIC ENANTIOSELECTIVE DEPROTONATION OF MESO-EPOXIDES UTILIZING HOMOCHIRAL BIS-LITHIUM AMIDE BASES

Authors
TIERNEY JP ALEXAKIS A MANGENEY P
Citation
Jp. Tierney et al., CATALYTIC ENANTIOSELECTIVE DEPROTONATION OF MESO-EPOXIDES UTILIZING HOMOCHIRAL BIS-LITHIUM AMIDE BASES, Tetrahedron : asymmetry, 8(7), 1997, pp. 1019-1022
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
7
Year of publication
1997
Pages
1019 - 1022
Database
ISI
SICI code
0957-4166(1997)8:7<1019:CEDOMU>2.0.ZU;2-9
Abstract
(R)-2-Cyclohexen-1-ol and (R)-2-cyclooctene-1-ol have been prepared in very good ee using R,R-homochiral bis-lithium amide bases derived fro m homochiral C-2 symmetric diamines. (R)-2-Cyclohexen-1-ol has been sy nthesized in good ee utilising catalytic homochiral bis-lithium amide in the presence of n-butyl lithium. (C) 1997 Elsevier Science Ltd.