LIPASE-CATALYZED RESOLUTION OF FERROCENE CYANOHYDRIN - ACCESS TO NOVEL FERROCENYL AMINOALCOHOLS AND DIAMINES

Authors
HOWELL JAS HUMPHRIES K MCARDLE P CUNNINGHAM D NICOLOSI G PATTI A WALSH MA
Citation
Jas. Howell et al., LIPASE-CATALYZED RESOLUTION OF FERROCENE CYANOHYDRIN - ACCESS TO NOVEL FERROCENYL AMINOALCOHOLS AND DIAMINES, Tetrahedron : asymmetry, 8(7), 1997, pp. 1027-1030
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
7
Year of publication
1997
Pages
1027 - 1030
Database
ISI
SICI code
0957-4166(1997)8:7<1027:LROFC->2.0.ZU;2-5
Abstract
(R)-(+)-Ferrocene cyanohydrin acetate, obtained by enzymatic acylation of ferrocene cyanohydrin, may be transformed by reduction and alkylat ion into novel ferrocenyl P-aminoalcohols. Substitution of acetate by methanolic HNMe2 proceeds with racemisation, but significant diastereo selection is observed on Strecker reaction using (-)-PhCH(Me)NHMe. (C) 1997 Elsevier Science Ltd.