THE STEREOSELECTIVE PREPARATION OF BETA-HYDROXY ESTERS USING A YEAST REDUCTION IN AN ORGANIC-SOLVENT

Authors
MEDSON C SMALLRIDGE AJ TREWHELLA MA
Citation
C. Medson et al., THE STEREOSELECTIVE PREPARATION OF BETA-HYDROXY ESTERS USING A YEAST REDUCTION IN AN ORGANIC-SOLVENT, Tetrahedron : asymmetry, 8(7), 1997, pp. 1049-1054
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
7
Year of publication
1997
Pages
1049 - 1054
Database
ISI
SICI code
0957-4166(1997)8:7<1049:TSPOBE>2.0.ZU;2-P
Abstract
A range of (S)-beta-hydroxy esters has been prepared in high yield (56 -96%) and with very high enantioselectivity (>94%) using a yeast media ted reduction in light petroleum. It was found that the ester function ality had a marked effect on both the isolated yield and the quantity of yeast required to effect complete reduction. (C) 1997 Elsevier Scie nce Ltd.