MOENOMYCIN-A - NEW CHEMISTRY THAT ALLOWS TO ATTACH THE ANTIBIOTIC TO REPORTER GROUPS, SOLID SUPPORTS, AND PROTEINS

Authors
KEMPIN U HENNIG L KNOLL D WELZEL P MULLER D MARKUS A VANHEIJENOORT J
Citation
U. Kempin et al., MOENOMYCIN-A - NEW CHEMISTRY THAT ALLOWS TO ATTACH THE ANTIBIOTIC TO REPORTER GROUPS, SOLID SUPPORTS, AND PROTEINS, Tetrahedron, 53(52), 1997, pp. 17669-17690
Citations number
43
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
52
Year of publication
1997
Pages
17669 - 17690
Database
ISI
SICI code
0040-4020(1997)53:52<17669:M-NCTA>2.0.ZU;2-0
Abstract
Moenomycin A (18) on reaction with the diazonium salt derived from bif unctional (protected) 15 yields the coupling product 19 which on reduc tion is converted into the moenomycin thiol derivative 21. Thiol 21 ha s been used to prepare selectively moenomycin dansyl and biotin adduct s 26 and 28, respectively. This work was performed with the aim to use moenomycin as a tool for studies of the transglycosylation step in pe ptidoglycan biosynthesis. (C) 1997 Elsevier Science Ltd.