A CONVENIENT 2-STEP ONE-POT SYNTHESIS OF PHOSPHONAMIDATES

Authors
MLODNOSKY KL HOLMES HM LAM VQ BERKMAN CE
Citation
Kl. Mlodnosky et al., A CONVENIENT 2-STEP ONE-POT SYNTHESIS OF PHOSPHONAMIDATES, Tetrahedron letters, 38(51), 1997, pp. 8803-8806
Citations number
9
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
51
Year of publication
1997
Pages
8803 - 8806
Database
ISI
SICI code
0040-4039(1997)38:51<8803:AC2OSO>2.0.ZU;2-O
Abstract
Phosphonamidates are formed in high yield from a one-pot sequential re action of a phosphonyl dichloride with an alcohol and then an amine in the presence of catalytic 1H-tetrazole. Undesired disubstitution of t he phoshphonyl dichloride by the alcohol or the amine is minimal due t o the presence of tetrazole. (C) 1997 Elsevier Science Ltd.