IMMUNOREGULATORY ACTIVITIES OF L-4-OXALYSINE - AN IN-VITRO STUDY

The present study was undertaken by in vitro experiments to determine the effect of L-4-oxalysine (OXL), a new natural product in China, on immunological responses. The immunological parameters evaluated were o ne-way mixed lymphocyte reaction and interleukin-6 activity stimulated by lipopolysaccharide. The results showed that the immunological func tions of spleen cells from normal mice were significantly suppressed b y in vitro treatment of OXL. However, OXL markedly enhanced the immuno logical responses of spleen cells from mice bearing hepatoma-22 tumor. It was indicated that OXL exerted obvious immunoregulatory activities .