PARVOVIRUS B19 QUIESCENCE DURING THE COURSE OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN PERSONS WITH HEMOPHILIA

To detect and characterize parvovirus B19 infection during the course of progressive immune deficiency from human immunodeficiency virus (HI V), ten subjects enrolled in the Multicenter Hemophilia Cohort Study w ere followed for 6.4 to 15 years from HIV seroconversion through extre me immune deficiency. Four to five sera or plasma samples from each su bject, collected at predetermined CD4(+) lymphocyte levels, were teste d for immunoglobulin G (IgG) and M (IgM) B19 antibodies and DNA, All 4 2 samples were positive for B19 IgG antibodies, and three were weakly positive for IgM antibodies, Only one sample, collected coincident wit h HIV seroconversion, was unequivocally positive for B19 DNA, No persi stent hematologic adverse effects of B19 infection were observed, Thus , although B19 IgG antibodies are highly prevalent among HIV-infected persons with hemophilia or related disorders, B19 viremia and its hema tologic consequences were not detected, even with severe depletion of CD4(+) lymphocytes. if primary B19 infection occurs after immune defic iency, however, the consequences may be more adverse. (C) 1997 Wiley-L iss, Inc.