WALDENSTROMS-MACROGLOBULINEMIA AND CEREBR AL LYMPHOPLASMOCYTOID PROLIFERATION - THE BING-NEEL-SYNDROME - A NEW CASE-REPORT

Waldenstrom's disease is a B-cell, low grade lymphoma, secreting an im munoglobulin M, and is called immunocytoma. Neurological complications are frequent, but encephalopathies due to lymphoplasmocytoid infiltra tion are rare (Bing-Neel syndrome). Tumors, probably arising from conf luence of infiltrative areas, are exceedingly rare. The authors report the case of a 70-year-old man, suffering from a Waldenstrom's immunog lobulinemia, who underwent surgery for a right sided rolandic tumor in volving the vault, the dura-mater, and the cortex. On the CT scan, the tumor mimicked a meningioma. Histological study and immunohistologic stains confirmed the monoclonal nature of the tumor. Based on the revi ew of the literature, clinical and neuroradiological features of these infiltrative and tumoral rare lesions, as well as their histopathogen esis and treatment, are discussed.