MULTIPLE AND DE-NOVO ANEURYSMS IN EHLERS- DANLOS SYNDROME

Background and purpose. - In 1964, the first case of << de novo >> ane urysm has been reported by Graf and Hamby. The risk of late formation of aneurysm is unknown. Some factors could influence risk : history of hypertension, oral contraceptives, cigarette smoking. We report a rar e case of << de novo >> aneurysm associated with Ehlers-Danlos syndrom e. Results. - A 35-year-old female developed a subarachnoid hemorrhage (SAH). Angiography demonstrated 4 aneurysms. Five years before, she p resented a SAH. At that time, four vessels angiography demonstrated on ly one PICA aneurysm. A Ehlers-Danlos syndrome was suspected, which wa s demonstrated on skin biopsies. Conclusion. - At our knowledge, this is the first case of << de novo >> aneurysm associated with a Ehlers-D anlos syndrome.