HYPERFRACTIONATED RADIATION IN COMBINATION WITH LOCAL HYPERTHERMIA INTHE TREATMENT OF ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK - A PHASE I-II STUDY

Twenty-seven patients with cervical metastases from squamous cell head and neck tumours were treated with hyperfractionated XRT (total dose 69.60-76.80 Gy, 1.2 Gy b.i.d. five times a week) combined with a total of two to six sessions of superficial external HT. Acute local toxici ty was mild; as major acute side effects, only one ulceration was reco rded. No severe late side effects were observed. Late toxicity was sim ilar to that observed in our previous studies with the combination of heat and radiation. Nodal complete response was observed in 77% of pat ients, partial response was observed in 15% of patients and no change was observed in 8% of patients. Five-year actuarial nodal control was 64.5 +/- 19% and 5-year actuarial survival was 24 +/- 10%. The treatme nt of nodal metastases from head and neck tumours with the combination of HT and hyperfractionated XRT is feasible with an acceptable acute and late toxicity profile. (C) 1997 Elsevier Science ireland Ltd.