Nj. Lynch et al., CHARACTERIZATION OF THE RAT AND MOUSE HOMOLOGS OF GCLQBP, A 33 KDA GLYCOPROTEIN THAT BINDS TO THE GLOBULAR HEADS OF CLQ, FEBS letters, 418(1-2), 1997, pp. 111-114
gC1qBP is a 33 kDa glycoprotein that binds to the globular 'heads' of
C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1
qBPP. Comparison of the cDNA-derived amino acid sequences of gC1qBP re
veals that either of the rodent sequences is 89.9% identical to the re
ported human sequence. Recombinant rat gC1qBP binds avidly to human C1
q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue a
nalysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1
qBP on the cell surface. In rat serum, gC1qBP is present at low levels
. (C) 1997 Federation of European Biochemical Societies.