A. Kadayifci et H. Simsek, DOES SMOKING INFLUENCE THE ERADICATION OF HELICOBACTER-PYLORI AND DUODENAL-ULCER HEALING WITH DIFFERENT REGIMENS, International journal of clinical practice, 51(8), 1997, pp. 516-517
To determine the effect of smoking on Helicobacter pylori eradication
and ulcer healing, we investigated 232 patients with H. pylori-positiv
e duodenal ulcer. Patients were given one of seven different treatment
protocols and divided into three groups according to smoking habits,
Group 1 (n=128) consisted of non-smokers, group 2 (n=65) of mild smoke
rs (5-20 cigarettes/day) and group 3 (n=39) of heavy smokers (>20/day)
. The eradication of H. pylori and ulcer healing rate was controlled e
ight weeks later after ceasing the therapy, The overall eradication ra
te was 66% in all patients and 68%, 66%, 59% in each group, respective
ly. The eradication rates showed no statistical difference between gro
ups. Complete ulcer healing was achieved in 84% of ail patients and ul
cer healing rate between groups did not show any significance (85%, 83
% and 82% respectively), These results suggest that smoking status doe
s not influence the eradication of H. pylori and duodenal ulcer healin
g rates at eight weeks in patients on different treatment schedules.