SYNTHESIS OF MODIFIED OLIGODEOXYRIBONUCLE OTIDES CONTAINING (2'-AMINO-2'-DEOXY-BETA-D-ARABINOFURANOSYL)ADENINE

Authors
ZUBIN EM ANTSYPOVICH SI ORETSKAYA TS ROMANOVA EA VOLKOV EM TASHLITSKII VN SHABAROVA ZA
Citation
Em. Zubin et al., SYNTHESIS OF MODIFIED OLIGODEOXYRIBONUCLE OTIDES CONTAINING (2'-AMINO-2'-DEOXY-BETA-D-ARABINOFURANOSYL)ADENINE, Bioorganiceskaa himia, 23(10), 1997, pp. 809-816
Citations number
16
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
23
Issue
10
Year of publication
1997
Pages
809 - 816
Database
ISI
SICI code
0132-3423(1997)23:10<809:SOMOOC>2.0.ZU;2-T
Abstract
A method for preparing a modified derivative of 2'-amino-2'-deoxy-arab ino-adenosine ready for directed insertion into an oligonucleotide cha in during solid-phase synthesis was elaborated. A series of the title oligonucleotides (6-25-mers) containing a 2'-amino-2'-deoxy-arabino-ad enosine fragment were prepared. A high reactivity of the 2'-amino grou p during the acylation with carboxylic acid anhydrides was demonstrate d. It was shown that the insertion of the modified fragments into olig onucleotides did not inhibit the formation of the DNA duplex.