REVERSAL OF ANTI TO SYN DIASTEREOSELECTIVITY IN CROTYLTITANATION REACTION

Authors
SZYMONIAK J THERY N MOISE C
Citation
J. Szymoniak et al., REVERSAL OF ANTI TO SYN DIASTEREOSELECTIVITY IN CROTYLTITANATION REACTION, Synlett, (11), 1997, pp. 1239
Citations number
16
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):11<1239:ROATSD>2.0.ZU;2-D
Abstract
eta(3)-2-Methylcrotyl(tiglyl)titanocene reacts with aldehydes to affor d anti homoallylic alcohols when the reaction is carried out in THF, a nd preferentially syn products when the solvent is HMPA/THF=3:1. This simple control of anti versus syn diastereoselectivity expands conside rably the synthetic uses of the crotyltitanation reaction.