COMPARISON OF IN-VITRO ANTIFUNGAL SUSCEPTIBILITIES OF CONIDIA AND HYPHAE OF FILAMENTOUS FUNGI

The MICs and minimum fungicidal concentrations (MFCs) of amphotericin B, fluconazole, ketoconazole, flucytosine, miconazole, and itraconazol e for 12 isolates of filamentous opportunistic fungi (Scopulariopsis s p., Paecilomyces sp., Cladosporium spp., and Cladophialophora sp.) wer e determined by a broth microdilution method with hyphal and conidial inocula. With hyphal inocula MICs and MFCs were practically always sub stantially higher. Only 25% of the 60 MIC comparisons showed discrepan cies of twofold or legs, while the remaining comparisons showed much l arger differences.