SULFATED CARBOHYDRATE COMPOUNDS PREVENT MICROBIAL ADHERENCE BY SEXUALLY-TRANSMITTED DISEASE PATHOGENS

Authors
HEROLD BC SISTON A BREMER J KIRKPATRICK R WILBANKS G FUGEDI P PETO C COOPER M
Citation
Bc. Herold et al., SULFATED CARBOHYDRATE COMPOUNDS PREVENT MICROBIAL ADHERENCE BY SEXUALLY-TRANSMITTED DISEASE PATHOGENS, Antimicrobial agents and chemotherapy, 41(12), 1997, pp. 2776-2780
Citations number
53
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
12
Year of publication
1997
Pages
2776 - 2780
Database
ISI
SICI code
0066-4804(1997)41:12<2776:SCCPMA>2.0.ZU;2-R
Abstract
Heparan sulfate (HS) serves as a receptor for adherence of herpes simp lex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indire ctly, human immunodeficiency virus. Using primary human culture system s, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds ar e candidates for intravaginal formulations for the prevention of sexua lly transmitted diseases.